Can not wearing panties cause an infection?

No. People wear underwear to feel comfortable and keep their clothes clean. Most people wear underwear for those reasons, but it’s totally up to you.

If you do wear underwear, it’s important to make sure you change into a clean, dry pair every day. It’s also important to avoid sitting around in a wet pair of underwear or a wet bathing suit for very long, because that can lead to infections.

-Emily at Planned Parenthood